Valves for the beverages and food, biotechnology, cosmetics, semiconductor, and pharmaceutical industries are classified in 3 levels of cleanliness: ultra-high purity, aseptic, and sanitary. Beverages and food use the term aseptic or sanitary. The biopharma may tend to use aseptic as well as sterile and sanitary. Semiconductor producers use the term top purity when referring to valves used for their processes. Valves in cleanrooms and aseptic processing must be perfect and rated (temperature, force, or caustic capable) for sterilization-in-place and clean-in-place. The valves are made to be self-draining and without threads. This is done to stop a “hold-up” volume of condensate, water, or process fluid, removing places for bacteria to grow. Kp-Lok

Food and beverage industry

In the beverage and food industry, the valves are made of 316L stainless steel. Many of the valves are rising stem control or off/on valves. These valves are located in the process line, aseptic filling operation, or packaging area. Valves in the industry are eighty to ninety percent pneumatically operated. To block the process line, a PTEE ring is included to the valve. The valves are made to self-drain if installed vertically, and choices can be included to permit horizontal installation to self-drain. Back force and throttling are also applied in this industry. Butterfly valves are general in this market, and diaphragm valves particularly efficient for filling applications. Important elements in diaphragm selection contain resistance to compression, media compatibility, closure performance, flex and regulatory compliance.

Semiconductor industry

The semiconductor industry uses very pure water in its processes. Those valves are made of PVDF. These valves are off/on and force relief in the size of 1/2 inch to twelve inches. More valves in the market are by hand operated rather than actuated. The valves for very pure water applications are butterfly or diaphragm types. They are made in a clean room and then twin-bagged.

Best Way to Clean Stainless Steel in process of manufacturing valves

Pharmaceutical and biotechnology industry

Biopharmaceutical manufacture is a batch process. As an outcome, cleaning after each bath is very vital; many valves are used specifically in the cleaning steps. Generally, less than ten percent of the full valves are used to regulate or control a process fluid, clean steam or a utility liquid or gas.  Examples would be the use of control valves to regulate some process inputs and the regulators to control the flow or control valves or regulate the force of clean steam, clean gases, and WFI.

The majority of full valve content is off/on diaphragm valves, and, to a lesser extent, ball valves and These off/on valves are used in CIP processing, WFI, process fluids, SIP processing, and other utilities such as bases or acids for pH control, sparge gases such as CO2 and O2.

As described previously, force and flow rates of these gas streams are regularly regulated by rising stem control regulators and valves, and there are diaphragm valves used in the same lines for off/on control. The process line valves are used in such places as growth media feedstock and sometimes finished items.